University of Delaware OEIP
University of Delaware

Biofunctional Thiophene Monomers

Technology #ud19-34

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We have developed a novel set of functionalized thiophene monomers with biologically active side groups. These new monomer designs make it possible to for us to create novel conjugated polymers that have precisely tailored properties for optimizing interactions with living tissue. These materials are being used in a wide variety of bioelectronic medical device applications including neural implants, cardiac pacemakers, and cochlear implants.


Poly(3,4-ethylene dioxythiophene) (PEDOT) is a conjugated polymer that has proven to be particularly useful for organic bioelectronics, both for biosensing and for integration of biodevices with living cells both in vitro and in vivo. However PEDOT is a relatively hydrophobic, biologically inert material that does not actively integrate with living tissue. This invention provides a simple and general method for the synthesis of functional thiophene monomers containing a wide variety of biologically active side groups. This technology provides a facile, convenient way for chemically attaching these biofunctional species to thiophene monomers and corresponding polythiophene polymers.


· Biofunctional thiophene monomers can now be readily created with precisely tailored biologically active side groups

· Biofunctional polythiophene polymers can now be created by chemical or electrochemical polymerization of these monomers on various substrates


These biofunctional monomers and corresponding polymers have tailored compositions and structures that now make it possible for us to optimize specific interactions of biomedical electronic devices with living tissue. They also have improved long-term stability and adhesion to solid substrates. 


The technology is patent pending. Further information on licensing opportunities is available on request.