Positron emission tomography (PET) is a non-invasive technique to track radiolabeled biomolecules in vivo. F-18 is the most commonly used radionuclides and there is a high demand for methods that efficiently introduce F-18 to biological macromolecules. Researchers at the University of Delaware have developed a second generation F-18 labeling system based on a conformational strained trans-cyclooctene (sTCO). An improvement in the existing technology, the biorthogonal reaction between tetrazines and trans-cyclooctenes is a method for the rapid construction of F-18 probes for PET imaging. Hence these tetrazine ligations employing F18-sTCO can serve as a powerful and general platform for the rapid construction of peptide or protein derived PET agents.
ranged, can be used to label all biomolecules.
faster than the current methods of F18 induction into the biomolecule.
- The radiolabeled-peptides constructed by this method display better pharmacokinetic properties
use in drug labeling and targeted drug delivery