Prox 1 is a protein that appears to regulate the transcription of genes important for the development of the ocular lens, liver, hair cells of the ear, and the lymphatic system. The invention is comprised of monoclonal antibodies against Prox1 of vertebrates and two continuous cell lines for their production. These antibodies are particularly useful in immunoassays to detect the presence of Prox1 protein in vertebrate tissues and cells. This ability is useful because Prox1 is one of the only known markers of the lymphatic system that has been proven consistently to tell lymphatic from blood vessels. The technology should be of interest to firms concerned with hepatocellular carcinomas, and users of other Prox1 immunoassay techniques.
When compared to existing polyclonal antibodies and cell lines for Prox1, the invention:
be used to prepare greater amounts of uniform antibodies
greater potential to be used as chemical reagents