University of Delaware OEIP
University of Delaware

Molecular Tool for Detection of Prox 1 Proteins (Markers for the Lymphatic System)

Technology #ud05-08

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Melinda K Duncan
Dr. Duncan’s laboratory focuses on understanding the pathogenesis of cataracts, the molecular mechanisms responsible for the side effects of cataract and other ocular surgeries, as well as the regulation of lens development and cellular differentiation.
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William Caine
Xioaren Chen
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Goswami Joy
Assistant Director, Technology Transfer Center 3028313547
Patent Protection

Hybridoma cell lines and monoclonal antibodies recognizing Prox1

US Patent US 7411049 B2

Technology Description:

Prox 1 is a protein that appears to regulate the transcription of genes important for the development of the ocular lens, liver, hair cells of the ear, and the lymphatic system. The invention is comprised of monoclonal antibodies against Prox1 of vertebrates and two continuous cell lines for their production.  These antibodies are particularly useful in immunoassays to detect the presence of Prox1 protein in vertebrate tissues and cells. This ability is useful because Prox1 is one of the only known markers of the lymphatic system that has been proven consistently to tell lymphatic from blood vessels. The technology should be of interest to firms concerned with hepatocellular carcinomas, and users of other Prox1 immunoassay techniques. 


When compared to existing polyclonal antibodies and cell lines for Prox1, the invention:

  • Can be used to prepare greater amounts of uniform antibodies 
  • Exhibits greater potential to be used as chemical reagents