at the University of Delaware have devised an innovative and novel method of amplifying
magnitude and duration of transgene expression. This method uses the collagen mimetic
(CMP) mediated delivery of non-viral DNA from collagen containing scaffolds.
of the polyplex used is variable, allowing customized release of the... Read More
(hydroxyalkanoates) (PHAs) are natural linear polyesters produced by bacteria
to store carbon and energy. The combination of different PHA monomers give rise
to materials with different mechanical properties, each with varied commercial
at the University of Delaware have devised an innovative and novel method of
production composite... Read More
chemistry has evolved into a field with broad reaching applications in biology,
medicine and materials science. The inverse-electron demand Diels-Alder
reaction of s-tetrazines
with alkene or alkyne dienophiles, referred to as tetrazine ligation, is a
prominent tool in the biorthogonal toolbox.
A notable aspect of the tetrazine ligation are the... Read More
emission tomography (PET) is a non-invasive technique to track radiolabeled
biomolecules in vivo.
F-18 is the most commonly used radionuclides and there is a high demand for
methods that efficiently introduce F-18 to biological macromolecules.
Researchers at the University of Delaware have
developed a second generation F-18 labeling system based on a... Read More
invention describes the use of a responsive hydrogel-based material as a
carrier system for in situ delivery of various bioactive moieties, including
small molecules, biomolecules, bio
but not limited to polysaccharides, glycosaminoglycans, proteins), and cells.
The novel chemistries presented will enable finely tuned local release... Read More
ud05-17 – Technology
present invention relates to a biologically active, functionalized, electro
spun matrix to permit immobilization and long-term delivery of biologically
active agents. In particular the
invention relates to a functionalized polymer matrix comprising a matrix
polymer, in which the matrix is modified by addition of a compatibilizing
polymer functionalized with a... Read More
invention provides a means to selectively control the degradation rates of
hydrogels and bio
conjugates, such as for drug release in the pharmaceutical industry or implants
in the biomaterials
industry. Addition of thiols and maleimides is widely used in preparing
and is known to lead to some product instabilities in vivo,
allowing the... Read More